Inhibition of ovulation

Cerazette effectively inhibits ovulation, even when a pill is taken up to 12 hours late.1,2,4 During a 1-year trial of Cerazette versus a traditional progestogen-only pill (POP) containing 30 µg of levonorgestrel, maximum progesterone levels were assessed to measure the effects of the pills on ovulation.2

  • Progesterone levels were < 10 nmol/l, signifying no ovulation, in 97% of Cerazette treatment cycles.2
  • Progesterone levels were > 30 nmol/l, indicating ovulation in only one (3%) of Cerazette treatment cycles in the twelfth treatment cycle, with no ovulations in the seventh treatment cycle.2
  • In comparison, ovulation occurred in 38% and 39% of women in the levonorgestrel group in the seventh and twelfth treatment cycles, respectively, a statistically significant difference when compared with Cerazette.2

Another study found that Cerazette inhibits ovulation even when a pill is taken 12 hours late.4 Just over 100 women took part in the 56-day study and purposely took Cerazette 12 hours late on three scheduled dates. Progesterone levels were measured every 2 days and showed that it took at least 7 days (mean 17.2 days) for ovulations to occur after stopping Cerazette.4

These two studies provide strong evidence of the ability of Cerazette to effectively inhibit ovulation.

Cerazette has a strong inhibitory effect on ovulation2

Cerazette has a strong inhibitory effect on ovulation

Adapted from Ref 2.
* p=0.001 comparing Cerazette values with those seen with the traditional POP. Ovulation is inhibited when maximum progesterone concentrations are below the threshold of 10 nmol/l (which indicates that the luteal phase of the menstrual cycles is absent or inadequate). Progesterone levels >30 nmol/l are indicative of ovulation.

 

 

Adverse events should be reported. Reporting forms and information can be found at www.yellowcard.gov.uk.
Adverse events should also be reported to MSD Drug Safety Department on 01707 363773

Organon

Date of Preparation 9/09
Job Code 9/12 - CZT.10.GB.42040.AV

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