Reliable contraception

The efficacy of Cerazette was established in a large, double blind, multicentre phase III trial. In this study, 979 women were given Cerazette and 327 women took a progestogen-only pill containing 30 µg of levonorgestrel. The study lasted for 1 year.3

In the Cerazette group, after excluding women for gross non-compliance, only one in-treatment pregnancy occurred during the whole study period, while three pregnancies were observed in the levonorgestrel group.3

The efficacy of contraceptives can be compared using the Pearl Index (the number of women getting pregnant per 100 users in 1 year). When the figures in the study were adjusted to include gross non-compliance, Cerazette had a Pearl Index of 0.4. In comparison, the Pearl Index for the levonorgestrel-containing pill was 1.55.3

The Pearl Index for Cerazette is comparable to the one historically found for combined oral contraceptives (COCs) in the general COC-using population.1

Contraceptive efficacy

Contraceptive efficacy

Adapted from Ref. 3.
†This study allowed a maximum of 3 hours for missed pills. A Pearl Index study using a 12-hour ‘missed-pill’ window is not available.

 

 

Adverse events should be reported. Reporting forms and information can be found at www.yellowcard.gov.uk.
Adverse events should also be reported to MSD Drug Safety Department on 01707 363773

Organon

Date of Preparation 9/09
Job Code 9/12 - CZT.10.GB.42040.AV

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